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Semax / Selank dosage

Compare the doses and schedules of Semax, Selank and calculate each component separately.

Full Semax / Selank library reference

Semax / Selank dosage chart

This summary compares component doses by route. These are separate component amounts, not a combined blend dose.

Component / routeDoseFrequency & duration
Semax · Intranasal300–600 mcg/day1-2 times daily · 4-12 weeks
Semax · Injectable~300 mcgDaily · 4–12 wk
Selank · Intranasal250–400 mcg/day1-2 times daily · 2-6 weeks
Selank · Injectable~250 mcgDaily · 2–6 wk

Semax / Selank dosage by administration route

Semax · Intranasal

Reported intranasal protocols use 300–600 mcg per day, divided across 1-2 administrations daily for 4-12 weeks.[7][1][8]

Semax is an ACTH-fragment analogue associated with neurotrophic and stress-response signaling. Nasal formulations have their own concentrations and delivery volumes.[1][8][9]

Semax · Injectable

Reported-use amounts for Semax are ~300 mcg per administration, daily, for 4–12 wk. Another reported once-daily subcutaneous progression uses 200 mcg in weeks 1–2, 300 mcg in weeks 3–4, 400 mcg in weeks 5–6 and 500 mcg in weeks 7–12. The same source also lists a separate 6–8-week course followed by 2–4 weeks off; these are not nasal-product directions.[16][17]

Injectable Semax is a separate preparation of the ACTH-fragment analogue. Nasal concentration and spray volume do not define an injectable amount.[1][8][9][16]

Selank · Intranasal

Reported intranasal protocols use 250–400 mcg per day, divided across 1-2 administrations daily for 2-6 weeks.[14][3][4]

Selank is a tuftsin-derived peptide associated with anxiety and stress-response signaling. Nasal concentration and the volume delivered per application determine the actual amount.[3][4][15]

Selank · Injectable

Reported-use amounts for Selank are ~250 mcg per administration, daily, for 2–6 wk. A reported subcutaneous progression uses 300 mcg once daily for weeks 1–2 and 500 mcg once daily for weeks 3–4, followed by four weeks off. This four-week-on/four-week-off pattern is not a nasal formulation schedule.[16][18]

Injectable Selank is a separate preparation of the tuftsin-derived peptide. Nasal concentration and delivered spray volume do not define its injection amount.[3][4][15][16]

Frequency and timing

Semax: Morning or afternoon is the listed timing for the nasal and injection patterns.[7][1][8][16]

Selank: Afternoon or evening is the listed timing for the nasal and injection patterns.[14][3][4][16]

Cycle length and breaks

Semax: Intranasal: 4-12 weeks. Injectable: 4–12 wk. A separate reported subcutaneous cycle pattern uses 6–8 weeks on, followed by 2–4 weeks off; nasal schedules differ.[7][1][8][16][17]

Selank: Intranasal: 2-6 weeks. Injectable: 2–6 wk. A separate reported subcutaneous cycle pattern uses four weeks on followed by four weeks off; nasal schedules differ.[14][3][4][16][18]

Semax / Selank dosage calculator

Calculate each separately prepared component using its own vial strength and final volume. A fixed-ratio blend requires the amount of every component; the total blend weight alone is insufficient.

Semax dosage calculator

Editable calculation example. Enter your chosen amount and the details of your vial; these starting values are not a recommended dose.

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See the reconstitution guidelines for preparation terms. For the distinction between separate preparations and mixed vials, read the mixing versus co-scheduling explainer.

Semax / Selank safety and side effects

Combination and product quality

A standardized combined Semax and Selank regimen is not established. Spray concentration and delivered volume determine each component amount. Headache, irritability, anxiety and sleep changes can overlap with effects from caffeine, stimulants and other neuroactive medicines.[2][4][3][6]

Side effects and long-term safety

Semax: Nasal irritation, headache, sleep disruption and overstimulation are practical tolerability concerns. Long-term repeated intranasal use, interactions, pregnancy and pediatric safety remain poorly characterized.[1][8][9][10]

Selank: Nasal irritation, fatigue, headache and calm or sedating effects are practical tolerability concerns. Long-term intranasal use, medication interactions, pregnancy and pediatric safety remain poorly characterized.[3][4][15][5]

Route-specific dosing limits

Separate products and fixed-ratio blends have different preparation requirements. Keep the exact formulation, component amount and route with each recorded dose. Reported-use schedules for Semax (injectable) and Selank (injectable) are not established human treatment regimens.[16][17][18]

Peptides in Semax / Selank

Open each full dosage guide for its routes, schedules and references.

All peptide and stack dosage guides →

Common Semax / Selank dosage questions

Does Semax / Selank have one combined dose?

Each component has its own amount and schedule. A stack name does not define a blend ratio or combined dose.

Can the component doses be calculated separately?

Yes, for separately prepared components. Use each vial's peptide amount and final volume in the calculator. A combined vial requires its exact component composition.

Does one spray always represent the same dose?

No. The amount depends on both concentration and the volume delivered by the specific spray device. Semax and Selank bottles can deliver different amounts per spray.[1][2][3][4][5][6]

What cycle and break patterns are listed for the components?

Semax: Intranasal: 4-12 weeks. Injectable: 4–12 wk. A separate reported subcutaneous cycle pattern uses 6–8 weeks on, followed by 2–4 weeks off; nasal schedules differ.[7][1][8][16][17]

Selank: Intranasal: 2-6 weeks. Injectable: 2–6 wk. A separate reported subcutaneous cycle pattern uses four weeks on followed by four weeks off; nasal schedules differ.[14][3][4][16][18]

Sources

Show citationsHide citations
[1]Semax, an analog of ACTH((4-7)), regulates expression of immune response genes during ischemic brain injury in rats.Mol Genet Genomics, 2017 Jun. animal.[2]Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress.Eur J Pharmacol, 2024 Dec 5. animal.[3][Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia].Zh Nevrol Psikhiatr Im S S Korsakova, 2008. human clinical.[4]Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity.Protein Pept Lett, 2018. review.[5]Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats.Bull Exp Biol Med, 2019 Sep. animal.[6]Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance.PubMed / Sports Medicine, 2026. review.[7]Search Drugs@FDA for SemaxU.S. Food and Drug Administration. database query.[8]Novel Insights into the Protective Properties of ACTH((4-7))PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion in Rats.Genes (Basel), 2020 Jun 22. animal.[9]Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats.Neuropeptides, 2021 Apr. animal.[10]Brain Protein Expression Profile Confirms the Protective Effect of the ACTH((4-7))PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia-Reperfusion.Int J Mol Sci, 2021 Jun 8. animal.[11]Compounding and the FDA: Questions and AnswersU.S. Food and Drug Administration. official guidance.[12]Bulk Drug Substances Used in Compounding Under Section 503A of the FD&C ActU.S. Food and Drug Administration, 2026-05-14. official guidance.[13]Bulk Drug Substances Used in Compounding Under Section 503B of the FD&C ActU.S. Food and Drug Administration, 2025-01-07. regulatory.[14]Search Drugs@FDA for SelankU.S. Food and Drug Administration. database query.[15][Immunomodulatory effects of selank in patients with anxiety-asthenic disorders].Zh Nevrol Psikhiatr Im S S Korsakova, 2008. human clinical.[16]PepFlow peptide cheat sheet — reported-use and product-orientation reference (not clinical research)PepFlow. reference catalog.[17]Semax — Everything Peptide reported protocol (educational reference, not clinical evidence)Everything Peptide. reference catalog.[18]Selank — Everything Peptide reported protocol (educational reference, not clinical evidence)Everything Peptide. reference catalog.

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