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Semax dosage

Compare Semax nasal daily totals with injection amounts and progressions, keeping divided doses and single administrations distinct. Calculate volume and syringe units using your own vial inputs.

Full Semax library reference

Semax dosage chart

This summary table compares available dose amounts and schedules by administration route.

RouteDoseFrequency & duration
Intranasal300–600 mcg/day1-2 times daily · 4-12 weeks
Injectable~300 mcgDaily · 4–12 wk

Semax dosage by administration route

Semax intranasal dosage

Reported intranasal protocols use 300–600 mcg per day, divided across 1-2 administrations daily for 4-12 weeks.[1][2][3]

Semax is an ACTH-fragment analogue associated with neurotrophic and stress-response signaling. Nasal formulations have their own concentrations and delivery volumes.[2][3][4]

Semax injectable dosage

Reported-use amounts for Semax are ~300 mcg per administration, daily, for 4–12 wk. Another reported once-daily subcutaneous progression uses 200 mcg in weeks 1–2, 300 mcg in weeks 3–4, 400 mcg in weeks 5–6 and 500 mcg in weeks 7–12. The same source also lists a separate 6–8-week course followed by 2–4 weeks off; these are not nasal-product directions.[11][12]

Injectable Semax is a separate preparation of the ACTH-fragment analogue. Nasal concentration and spray volume do not define an injectable amount.[2][3][4][11]

Frequency and timing

Morning or afternoon is the listed timing for the nasal and injection patterns.[1][2][3][11]

Cycle length and breaks

Intranasal: 4-12 weeks. Injectable: 4–12 wk. A separate reported subcutaneous cycle pattern uses 6–8 weeks on, followed by 2–4 weeks off; nasal schedules differ.[1][2][3][11][12]

Semax dosage calculator

Convert your chosen Semax amount into volume and U-100 syringe units. Adjust the inputs to match your vial and preparation.

Semax dosage calculator

Editable calculation example. Enter your chosen amount and the details of your vial; these starting values are not a recommended dose.

mcg
mg
mL
Concentration
5mg/mL
Draw units
—units
Total doses
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Volume per dose
—mL
Daily amount
—mcg
Complete days per vial
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Semax safety and side effects

Approval and product quality

Semax is not an FDA-approved drug.[1][8][9][10]

Side effects and long-term safety

Nasal irritation, headache, sleep disruption and overstimulation are practical tolerability concerns. Long-term repeated intranasal use, interactions, pregnancy and pediatric safety remain poorly characterized.[2][3][4][5]

Route-specific dosing limits

Mood state, neurologic history, and intranasal formulation quality drive the main cautions. Reported-use injectable schedules and additional protocol patterns are not established human treatment regimens or approved product instructions.[2][3][4][5][12][11]

Stacks that include Semax

Open a stack dosage guide for its component amounts, schedules and supporting information.

For a blend calculation, each component's amount and the final volume must be known. A total blend weight alone cannot tell you the dose of each component.

Common Semax dosage questions

Is the listed Semax amount a daily total?

Amounts marked /day are the total for the day. They are not an amount to repeat at each administration; the amount per administration depends on how that total is divided.[1][2][3]

What dosage is listed for Semax?

Reported intranasal protocols use 300–600 mcg per day, divided across 1-2 administrations daily for 4-12 weeks.[1][2][3]

Does Semax have a standard cycle or break interval?

Intranasal: 4-12 weeks. Injectable: 4–12 wk. A separate reported subcutaneous cycle pattern uses 6–8 weeks on, followed by 2–4 weeks off; nasal schedules differ.[1][2][3][11][12]

Sources

Show citationsHide citations
[1]Search Drugs@FDA for SemaxU.S. Food and Drug Administration. database query.[2]Semax, an analog of ACTH((4-7)), regulates expression of immune response genes during ischemic brain injury in rats.Mol Genet Genomics, 2017 Jun. animal.[3]Novel Insights into the Protective Properties of ACTH((4-7))PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion in Rats.Genes (Basel), 2020 Jun 22. animal.[4]Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats.Neuropeptides, 2021 Apr. animal.[5]Brain Protein Expression Profile Confirms the Protective Effect of the ACTH((4-7))PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia-Reperfusion.Int J Mol Sci, 2021 Jun 8. animal.[6][Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia].Zh Nevrol Psikhiatr Im S S Korsakova, 2008. human clinical.[7]Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity.Protein Pept Lett, 2018. review.[8]Compounding and the FDA: Questions and AnswersU.S. Food and Drug Administration. official guidance.[9]Bulk Drug Substances Used in Compounding Under Section 503A of the FD&C ActU.S. Food and Drug Administration, 2026-05-14. official guidance.[10]Bulk Drug Substances Used in Compounding Under Section 503B of the FD&C ActU.S. Food and Drug Administration, 2025-01-07. regulatory.[11]PepFlow peptide cheat sheet — reported-use and product-orientation reference (not clinical research)PepFlow. reference catalog.[12]Semax — Everything Peptide reported protocol (educational reference, not clinical evidence)Everything Peptide. reference catalog.

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