Tirzepatide dosage chart
This summary table compares available dose amounts and schedules by administration route.
| Route | Dose | Frequency & duration |
|---|---|---|
| Injectable | 2.5 mg starting dose; maintenance varies by product | Once weekly · Ongoing |
| Sublingual | 4.5 → 6 → 7.5 → 9 mg (compounded 15 mg/mL suspension) | Once daily · 4-week introductory schedule |
Tirzepatide dosage by administration route
Tirzepatide injectable dosage
Tirzepatide starts at 2.5 mg once weekly for 4 weeks, then increases to 5 mg weekly; further increases are 2.5 mg at intervals of at least 4 weeks. For Mounjaro, the adult maximum is 15 mg weekly and the pediatric maximum is 10 mg weekly. Zepbound maintenance doses are 5 mg, 10 mg, or 15 mg weekly for weight reduction and 10 mg or 15 mg weekly for obstructive sleep apnea. An alternative schedule uses 2.5 mg weekly in weeks 1–4, 5 mg in weeks 5–8, 7.5 mg in weeks 9–12 and 10 mg from week 13. These are escalation steps, not a requirement to increase at every step; they do not replace product-specific maintenance doses up to 15 mg.[1][2][10]
Tirzepatide activates both GIP and GLP-1 receptors. Labeled injectable products may support weight management or type 2 diabetes control in their indicated populations.[1][2][3][4]
Tirzepatide sublingual — compounded 15 mg/ml suspension dosage
A specific compounded sublingual suspension contains 15 mg/mL tirzepatide. Its introductory schedule uses 0.3 mL daily in week 1, 0.4 mL in week 2, 0.5 mL in week 3 and 0.6 mL in week 4, corresponding to 4.5, 6, 7.5 and 9 mg per administration. These formulation-specific directions are not dose equivalents for weekly injections.[11]
Tirzepatide acts at GIP and GLP-1 receptors. A reproducible absorption profile and treatment effect from a sublingual preparation have not been established.[5][6][1][2][3][4]
Frequency and timing
For injections, use the same day each week, at any time and with or without food. A missed injection can be taken within 4 days; after that, skip it and resume the regular weekly schedule. These instructions apply to injections, not the daily compounded sublingual preparation.[1][2][11]
Tirzepatide dosage calculator
Convert your chosen Tirzepatide amount into volume and U-100 syringe units. Adjust the inputs to match your vial and preparation.
Tirzepatide safety and side effects
Approval and product quality
Tirzepatide injection appears in FDA-approved labeling for Zepbound and Mounjaro; indication depends on the specific product label.[1][2]
Side effects and long-term safety
Gastrointestinal symptoms are common, particularly during dose escalation. The prescription label also addresses serious risks and interactions that depend on the treatment context.[1][2]
Route-specific dosing limits
Key cautions are the boxed thyroid C-cell tumor warning, pancreatitis or gallbladder disease, dehydration-related kidney risk, hypoglycemia with insulin or sulfonylureas, oral contraceptive exposure, and unapproved GLP-1/GIP products. Additional schedules attributed to Everything Peptide are reported patterns; citing research does not make these schedules clinically established or approved product instructions.[1][2][9][10]
