Semaglutide dosage chart
This summary table compares available dose amounts and schedules by administration route.
| Route | Dose | Frequency & duration |
|---|---|---|
| Injectable | 0.25 → 0.5 → 1 → 1.7 → 2.4 mg; 7.2 mg where indicated (Wegovy) | Once weekly · Escalation steps at least 4 weeks · Ongoing |
| Injectable | 0.25 → 0.5 → 1 → 2 mg (Ozempic) | Once weekly · Escalation steps at least 4 weeks · Ongoing |
| Oral | 1.5 → 4 → 9 → 25 mg (Wegovy tablets) | Once daily · Escalation steps 30 days · Ongoing |
| Oral | 3 → 7 → 14 mg (Rybelsus) | Once daily · Escalation steps 30 days · Ongoing |
| Oral | 1.5 → 4 → 9 mg (Ozempic tablets) | Once daily · Escalation steps 30 days · Ongoing |
Semaglutide dosage by administration route
Semaglutide injectable dosage
Wegovy injection starts at 0.25 mg once weekly for 4 weeks, then increases every 4 weeks to 0.5 mg, 1 mg, and 1.7 mg. Maintenance is 1.7 mg or 2.4 mg weekly for weight reduction or cardiovascular risk reduction, and 2.4 mg weekly for MASH. For adult weight reduction, Wegovy HD may increase to 7.2 mg weekly after at least 4 weeks tolerating 2.4 mg when further weight reduction is indicated. Ozempic starts at 0.25 mg once weekly for 4 weeks, then 0.5 mg weekly; maintenance doses are 0.5 mg, 1 mg, or 2 mg weekly, with increases no sooner than every 4 weeks. A reported weekly weight-management progression uses 0.25 mg for weeks 1–4, 0.5 mg for weeks 5–8, 1 mg for weeks 9–12, 1.7 mg for weeks 13–16 and 2.4 mg from week 17. Product-specific maintenance choices remain governed by the current Wegovy or Ozempic instructions above.[1][2][11]
Semaglutide activates GLP-1 receptors involved in appetite and glucose regulation. The appropriate labeled product may support weight management or type 2 diabetes control.[1][2][3][4][5][6]
Semaglutide oral dosage
Wegovy tablets start at 1.5 mg once daily for 30 days, then 4 mg daily for 30 days, 9 mg daily for 30 days, and 25 mg daily thereafter. Rybelsus starts at 3 mg once daily for 30 days, then 7 mg daily; after 60 days it may remain at 7 mg or increase to 14 mg daily. Ozempic tablets start at 1.5 mg once daily for 30 days, then 4 mg daily; after 60 days they may remain at 4 mg or increase to 9 mg daily. These tablet products are not interchangeable milligram for milligram.[1][4]
Semaglutide activates GLP-1 receptors involved in appetite and glucose regulation. The appropriate labeled product may support weight management or type 2 diabetes control.[1][4][7][2][5][6]
Semaglutide dosage calculator
Convert your chosen Semaglutide amount into volume and U-100 syringe units. Adjust the inputs to match your vial and preparation.
Semaglutide safety and side effects
Approval and product quality
Semaglutide injection appears in FDA-approved drug labeling for products such as Wegovy and Ozempic; indications and dosing depend on the specific product. Semaglutide tablets appear in FDA-approved labeling for oral products; tablet indications and administration requirements are not interchangeable with injectable products.[1][2][4]
Side effects and long-term safety
Gastrointestinal intolerance is common and often related to dose escalation. Dehydration and diabetic retinopathy are additional practical concerns.[1][2][4]
Route-specific dosing limits
Key cautions include the boxed thyroid C-cell tumor warning, pancreatitis or gallbladder disease, hypoglycemia with insulin or sulfonylureas, pregnancy planning and unapproved GLP-1 products. Additional schedules attributed to Everything Peptide are reported patterns; citing research does not make these schedules clinically established or approved product instructions.[1][2][4][10][11]
