Peptide label key

Use this page to read PepFlow's tier grades, evidence percentages, safety labels, FDA status chips, and injectable 503A compounding labels consistently.

Jump To

Tiers

Tier colors preserve the existing PepFlow grade palette. Tier is a usefulness grade, not just an evidence score.

Label	Signal	Meaning	Rationale
S	Top tier	Highest practical usefulness with strong, clinically established evidence.	Reserved for entries where the claim is both useful and unusually well supported.
A	High tier	Strong usefulness with substantial human evidence.	Used when a peptide has a clear practical role and the supporting evidence is broad enough for high confidence.
B	Useful tier	Useful, with moderate or promising human evidence and clear caveats.	A good signal, but still limited by route, formulation, outcome size, or source maturity.
C	Mixed tier	Mixed or emerging evidence; useful context but not settled.	The peptide may be worth tracking, but the page should not read like the benefit is established.
D	Early tier	Preliminary or indirect evidence with meaningful limitations.	Usually driven by small studies, adjacent evidence, route mismatch, or mostly mechanistic support.
E	Weak tier	Mostly preclinical, weak, or low-usefulness evidence.	The claim may be biologically plausible, but it is not ready for practical confidence.
F	Insufficient tier	Insufficient reviewed evidence for practical usefulness.	Used when PepFlow should avoid implying a usable effect from the reviewed source base.
WIP	Not reviewed	The record is present, but its evidence, safety, or regulatory review is not complete.	Neutral prevents missing review work from looking like either a low grade or a safety signal.

Evidence percentages

Evidence percentages summarize confidence in the reviewed claim. Each label uses its own display band.

Label	Percent	Meaning	Rationale
Strong	80-100%	Consistent human data, approved-label context, or very strong clinical support.	This is the highest evidence-confidence bucket and should stay route-specific.
Moderate	65-79%	Some direct human evidence plus coherent preclinical or mechanistic support.	Enough support to discuss confidently, while keeping limitations visible.
Emerging	50-64%	Early or limited human data exists, usually narrow, indirect, uncontrolled, or not yet replicated.	Keeps the chip in the same confidence-language family while the detail text explains the human-data limits.
Preliminary	35-49%	Early signals, active trials, indirect human context, or plausible translational support.	Marks a lower-confidence stage without mixing source type into the chip label.
Limited	20-34%	Mostly animal, cell, formulation, or mechanism data, with little direct human outcome support.	Keeps biological plausibility visible without making the chip compete with the rest of the scale.
Insufficient	1-19%	Not enough reviewed evidence for a confident claim.	Prevents weak or unsupported claims from looking merely early-stage.
Not Reviewed	0%	No evidence assessment has been added yet.	Neutral means missing review, not proof that the peptide does or does not work.

Safety labels

Safety labels describe the caution context. A peptide can have strong evidence and still need strict safety or route limits.

Label	Signal	Meaning	Rationale
Well-Studied	Best-characterized	Substantial human safety data exists for the same molecule, route, and typical use. This does not mean risk-free.	Use only when the relevant human safety profile is mature enough to be well characterized.
Moderate Data	Some safety context	Relevant human safety data exists, but it is smaller, shorter, narrower, or less complete than a well-studied profile.	Use when the evidence supports practical safety context without supporting a mature or broadly established profile.
Limited Data	Higher uncertainty	Relevant human safety data is sparse, indirect, route-mismatched, or too early to characterize the typical use confidently.	Use for evidence uncertainty. Lack of approval, a sports prohibition, or one contaminated batch does not determine this label by itself.
High Caution	High caution	Serious human harm or an explicit authoritative avoid or stop warning is relevant to the same molecule, route, and typical use.	Use only when the concern is attributable to the substance or use—not merely lack of approval, limited data, sports prohibition, or one contaminated product batch.
Not Reviewed	Not reviewed	The route- and use-specific safety classification has not been completed.	This is a review state, not a judgment that the substance is safe or dangerous.

FDA / regulatory

Regulatory labels are reusable status buckets for FDA approval, compounding, cosmetics, sport rules, and future regulatory systems. The page detail explains the specific entity and route.

Label	Signal	Meaning	Rationale
Approved	Authorized	An approval or authorization exists for the reviewed product, route, or claim context.	The chip stays reusable; the page detail should identify the regulator, product, indication, route, and label.
Not Approved	No approval identified	No approval or authorization is identified for the reviewed product, route, or claim context.	This is red because readers often confuse availability, research use, or compounding with approval.
Non-Drug	Claim-specific context	The reviewed context is cosmetic, non-drug, or otherwise separate from therapeutic drug approval.	Keeps cosmetic or non-drug availability separate from an approved medical claim.
Under Review	Review in progress	A regulator, compounding process, or review body is still evaluating the status.	Under review does not mean approved, safe, prohibited, or clinically established.
Flagged	Restriction or risk flag	A regulatory safety-risk flag, restriction, exclusion, or sport/anti-doping prohibition applies.	Red is reserved for reviewed regulatory constraints that need visible caution.
Not Listed	No listing found	The substance, route, or product was not listed in the reviewed regulatory material.	Not listed is not an approval or safety statement.
Not Reviewed	Not reviewed	The regulatory status has not been reviewed for that page yet.	Neutral keeps unfinished content separate from a reviewed regulatory conclusion.

Injectable 503A

Injectable 503A uses the same simplified regulatory states, but it stays separate because injectable compounding has different sterility, impurity, and route-specific concerns.

Label	Signal	Meaning	Rationale
Under Review	Review in progress	The injectable route appears in a 503A evaluation bucket, but the review is not complete.	This is a process state, not approval.
Flagged	Safety-risk flag	The injectable compounding route has been tied to FDA safety-risk concerns.	Injectable exposure raises sterility, impurities, aggregation, immunogenicity, and dose-control questions.
Not Listed	No listing found	No reviewed injectable 503A listing was identified in the reviewed materials.	Not listed is not an approval, safety clearance, or recommendation.
Not Reviewed	Not reviewed	No reviewed injectable 503A status has been added yet.	Neutral keeps unfinished review separate from approval or safety-risk flags.